The risk of developing tardive dyskinesia and the likelihood that it will become irreversible are believed to increase as the duration of treatment and the total cumulative dose of antipsychotic drugs administered to the patient increase. However, the syndrome can develop, although much less commonly, after relatively brief treatment periods at low doses. Somnolence was a commonly reported adverse reaction in patients treated with Ziprasidone. In the 4- and 6-week placebo-controlled trials, somnolence was reported in 14% of patients on Ziprasidone compared to 7% of placebo patients. Before using this medication, tell your doctor or pharmacist your medical history, especially of: dementia, seizures, low white blood cell count, difficulty swallowing, heart disease such as coronary artery disease, irregular heartbeat diabetes including family history obesity. boots pharmacy dubai midamor
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. People with schizophrenia who get counseling are also more likely to stick with their medications. As with other antipsychotic drugs and placebo, sudden unexplained deaths have been reported in patients taking Ziprasidone at recommended doses. The premarketing experience for Ziprasidone did not reveal an excess risk of mortality for Ziprasidone compared to other antipsychotic drugs or placebo, but the extent of exposure was limited, especially for the drugs used as active controls and placebo. Nevertheless, Ziprasidone's larger prolongation of QTc length compared to several other antipsychotic drugs raises the possibility that the risk of sudden death may be greater for Ziprasidone than for other available drugs for treating schizophrenia.
Patients being considered for Ziprasidone treatment that are at risk of significant electrolyte disturbances should have baseline serum potassium and magnesium measurements. Low serum potassium and magnesium should be replaced before proceeding with treatment. Patients who are started on diuretics during Ziprasidone therapy need periodic monitoring of serum potassium and magnesium. Ziprasidone's efficacy in treating the positive symptoms of schizophrenia is believed to be mediated primarily via antagonism of the dopamine receptors, specifically D 2. Blockade of the 5-HT 2A receptor may also play a role in its effectiveness against positive symptoms, though the significance of this property in antipsychotic drugs is still debated among researchers. Blockade of 5-HT 2A and 5-HT 2C and activation of 5-HT 1A as well as inhibition of the reuptake of serotonin and norepinephrine may all contribute to its ability to alleviate negative symptoms.
Schotte A, Janssen PF, Gommeren W, et al. March 1996. Ziprasidone is well absorbed after oral administration, reaching peak plasma concentrations in 6 to 8 hours. The absolute bioavailability of a 20 mg dose under fed conditions is approximately 60%. The absorption of Ziprasidone is increased up to two-fold in the presence of food. Tatsumi M, Jansen K, Blakely RD, Richelson E March 1999. "Pharmacological profile of neuroleptics at human monoamine transporters". European Journal of Pharmacology. Ziprasidone is not approved for use in psychotic conditions related to dementia. Ziprasidone may increase the risk of death in older adults with dementia-related conditions.
This medication can decrease hallucinations and help you to think more clearly and positively about yourself, feel less agitated, and take a more active part in everyday life. Before taking Ziprasidone hydrochloride capsules, tell your doctor if you are pregnant or plan on becoming pregnant. It is advised that you don't breast feed an infant if you are taking Ziprasidone hydrochloride capsules. Ziprasidone hydrochloride capsules contain Ziprasidone hydrochloride monohydrate, lactose monohydrate, pregelatinized maize starch, and magnesium stearate. Hypotension and circulatory collapse should be treated with appropriate measures such as intravenous fluids. If sympathomimetic agents are used for vascular support, epinephrine and dopamine should not be used, since beta stimulation combined with α 1 antagonism associated with Ziprasidone may worsen hypotension. Similarly, it is reasonable to expect that the alpha-adrenergic-blocking properties of bretylium might be additive to those of Ziprasidone, resulting in problematic hypotension. Ziprasidone 20 and 60 mg twice daily with placebo, only the 60 mg dose was superior to placebo on the BPRS total score and the CGI severity score. This higher dose group was not superior to placebo on the BPRS psychosis cluster or on the SANS. Ziprasidone is contraindicated in individuals with a known hypersensitivity to the product. Ziprasidone should be used with particular caution in patients with known cardiovascular disease history of myocardial infarction or ischemic heart disease, heart failure or conduction abnormalities cerebrovascular disease, or conditions which would predispose patients to hypotension dehydration, hypovolemia, and treatment with antihypertensive medications. This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages. Adverse reactions during exposure were obtained by collecting voluntarily reported adverse experiences, as well as results of physical examinations, vital signs, weights, laboratory analyses, ECGs, and results of ophthalmologic examinations. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. There are some medications that may be unsafe to use when taking Ziprasidone hydrochloride, and there are some medicines that can affect how well Ziprasidone hydrochloride works. Ziprasidone has not been evaluated or used to any appreciable extent in patients with a recent history of myocardial infarction or unstable heart disease. Patients with these diagnoses were excluded from premarketing clinical studies. QTc prolongations may also increase risk, or increase it in susceptible individuals. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Lifetime carcinogenicity studies were conducted with Ziprasidone in Long Evans rats and CD-1 mice. QT prolongation, recent acute myocardial infarction, uncompensated heart failure, or cardiac arrhythmia.
Baldassano CF, Ballas C, Datto SM, et al. February 2003. Do not drive a car or operate machinery until you know how this medication affects you. FDA, which approved the drug on February 5, 2001. Some side effects can be serious. In vivo studies have revealed no effect of Ziprasidone on the pharmacokinetics of estrogen or progesterone components. Alan F. Schatzberg; Charles B. Nemeroff February 10, 2006. If you develop any side effects that concern you, talk with your doctor. It is particularly important to tell your doctor if you have diarrhea, vomiting, or another illness that can cause you to lose fluids. Your doctor may want to check your blood to make sure that you have the right amount of important salts after such illnesses. This drug may also rarely cause significant weight gain and a rise in your blood cholesterol or triglyceride levels. These effects, along with diabetes, may increase your risk for developing heart disease. Discuss the risks and benefits of treatment with your doctor. Take Ziprasidone hydrochloride capsules with food. Approximately two-thirds of Ziprasidone is metabolized via a combination of chemical reduction by glutathione and enzymatic reduction by aldehyde oxidase. There are no known clinically relevant inhibitors or inducers of aldehyde oxidase. Less than one-third of Ziprasidone metabolic clearance is mediated by cytochrome P450 catalyzed oxidation. Antipsychotic drugs which include Ziprasidone hydrochloride may cause somnolence, postural hypotension, and motor and sensory instability, which could lead to falls and, consequently, fractures or other injuries. Other severe cutaneous adverse reactions, such as Stevens-Johnson syndrome, have been reported with Ziprasidone exposure. Severe cutaneous adverse reactions are sometimes fatal. Discontinue Ziprasidone if severe cutaneous adverse reactions are suspected. Wash and dry your hands before using. Clean and dry the affected area. If you are using the lotion or foam, shake it well just before using. If you are using the spray, check the product package to see if it needs to be shaken before each use. Apply a small amount of medication to the affected area and gently rub in, usually up to 4 times a day or as directed by your doctor or the product package. Dosage and length of treatment depends on the type of condition being treated. Do not bandage, cover, or wrap the area unless directed to do so by your doctor. desyrel
CBC monitored frequently during the first few months of therapy and should discontinue Ziprasidone hydrochloride at the first sign of decline in WBC in the absence of other causative factors. Ziprasidone hydrochloride capsules, 60 mg are size '3' capsules with white opaque cap and white opaque body, imprinted axially with "LU" on cap and "V53" on body in black ink, containing off-white to pinkish granular powder. QTc prolonging effect of oral Ziprasidone with several other drugs effective in the treatment of schizophrenia was conducted in patient volunteers. In the first phase of the trial, ECGs were obtained at the time of maximum plasma concentration when the drug was administered alone. In the second phase of the trial, ECGs were obtained at the time of maximum plasma concentration while the drug was co-administered with an inhibitor of the CYP4503A4 metabolism of the drug. Monti JM March 2010. "Serotonin 5-HT2A receptor antagonists in the treatment of insomnia: present status and future prospects. Class Ia and III anti-arrhythmics, mesoridazine, thioridazine, chlorpromazine, droperidol, pimozide, sparfloxacin, gatifloxacin, moxifloxacin, halofantrine, mefloquine, pentamidine, arsenic trioxide, levomethadyl acetate, dolasetron mesylate, probucol or tacrolimus. Keep Ziprasidone hydrochloride capsules and all medicines out of the reach of children. Keep all regular medical and laboratory appointments. Pooled data from short-term, placebo-controlled studies in schizophrenia are presented in Tables 1 to 2. Note that for the flexible dose studies in schizophrenia each subject is categorized as having received either low 20 to 40 mg BID or high 60 to 80 mg BID dose based on the subject's modal daily dose. Retrieved May 13, 2012. It is not known whether this drug passes into milk when applied to the skin. Newman-Tancredi A, Gavaudan S, Conte C, et al. August 1998. Ziprasidone was documented in 10 patients. All of these patients survived without sequelae. Rarely, males may have a painful or prolonged erection lasting 4 or more hours. If this occurs, stop using this drug and get medical help right away, or permanent problems could occur. Prolongation of the QTc interval is associated in some other drugs with the ability to cause torsade de pointes-type arrhythmia, a potentially fatal polymorphic ventricular tachycardia, and sudden death. In many cases this would lead to the conclusion that other drugs should be tried first. Ziprasidone hydrochloride and have their WBC followed until recovery. During pregnancy, this medication should be used only when clearly needed. average price furosemide furosemide
PDF. FDA. July 19, 2000. Its biological half-life time is 10 hours at doses of 80-120 milligrams. Gilman's The Pharmacological Basis of Therapeutics 12th Edition. China: McGraw-Hill. These metabolic changes include hyperglycemia, dyslipidemia, and body weight gain. While all of the drugs in the class have been shown to produce some metabolic changes, each drug has its own specific risk profile. Because Ziprasidone is highly metabolized, with less than 1% of the drug excreted unchanged, renal impairment alone is unlikely to have a major impact on the pharmacokinetics of Ziprasidone. There is a slight risk 1 in 1500 patients that ziprasidone by itself could significantly increase the QT interval. There is an even smaller risk 1 in 4000 patients that it could cause a potentially serious change in the rhythm of the heart. The recommends a gradual withdrawal when discontinuing antipsychotic treatment to avoid acute withdrawal syndrome or rapid relapse. Ziprasidone was tested in the Ames bacterial mutation assay, the in vitro mammalian cell gene mutation mouse lymphoma assay, the in vitro chromosomal aberration assay in human lymphocytes, and the in vivo chromosomal aberration assay in mouse bone marrow. There was a reproducible mutagenic response in the Ames assay in one strain of S. typhimurium in the absence of metabolic activation. Positive results were obtained in both the in vitro mammalian cell gene mutation assay and the in vitro chromosomal aberration assay in human lymphocytes. There are higher discontinuation rates for lower doses of Ziprasidone, which are also less effective than higher doses. doxazosin generic cost
Talk to your doctor about using ziprasidone safely. Retrieved June 4, 2015. It affects how you think and behave. This can show up in different ways and at different times, even in the same person. The illness usually starts in late adolescence or young adulthood. Ziprasidone may induce orthostatic hypotension associated with dizziness, tachycardia, and, in some patients, syncope, especially during the initial dose-titration period, probably reflecting its α 1-adrenergic antagonist properties. Nemeroff CB, Lieberman JA, Weiden PJ, et al. November 2005. Drug Reaction with Eosinophilia and Systemic Symptoms DRESS has been reported with Ziprasidone exposure. DRESS consists of a combination of three or more of the following: cutaneous reaction such as rash or exfoliative dermatitis eosinophilia, fever, lymphadenopathy and one or more systemic complications such as hepatitis, nephritis, pneumonitis, myocarditis, and pericarditis. DRESS is sometimes fatal. Discontinue Ziprasidone if DRESS is suspected. Alzheimer's dementia. Conditions that lower the seizure threshold may be more prevalent in a population of 65 years or older. Tschoner A, Engl J, Rettenbacher M, et al. January 2009.
Ziprasidone is unlikely to interfere with the metabolism of drugs metabolized by cytochrome P450 enzymes. You are currently taking medications that should not be taken in combination with Ziprasidone, for example, dofetilide, sotalol, quinidine, other Class Ia and III anti-arrhythmics, mesoridazine, thioridazine, chlorpromazine, droperidol, pimozide, sparfloxacin, gatifloxacin, moxifloxacin, halofantrine, mefloquine, pentamidine, arsenic trioxide, levomethadyl acetate, dolasetron mesylate, probucol or tacrolimus. Ziprasidone may cause a condition that affects the heart rhythm QT prolongation. Ziprasidone is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives and is indicated for the treatment of schizophrenia. Ziprasidone is a selective monoaminergic antagonist with high affinity for the serotonin Type 2 5HT2 dopamine Type 2 D2 1 and 2 adrenergic, and H1 histaminergic receptors. Ziprasidone acts as an antagonist at other receptors, but with lower potency. Antagonism at receptors other than dopamine and 5HT2 with similar receptor affinities may explain some of the other therapeutic and side effects of Ziprasidone. Ziprasidone's antagonism of muscarinic M1-5 receptors may explain its anticholinergic effects. Ziprasidone's antagonism of histamine H1 receptors may explain the somnolence observed with this drug. Ziprasidone's antagonism of adrenergic a1 receptors may explain the orthostatic hypotension observed with this drug. Tell your doctor if your condition persists or worsens. Dizziness caused by a drop in your blood pressure may occur with Ziprasidone hydrochloride, especially when you first start taking this medication or when the dose is increased. If this happens, be careful not to stand up too quickly, and talk to your doctor about the problem. Consistent with in vitro results, a study in normal healthy volunteers showed that Ziprasidone did not alter the metabolism of dextromethorphan, a CYP2D6 model substrate, to its major metabolite, dextrorphan. Who Should Take Ziprasidone Hydrochloride Capsules? Ziprasidone absorption is optimally achieved when administered with food. Without a meal preceding dose, the bioavailability of the drug is reduced by approximately 50%. In case of acute overdosage, establish and maintain an airway and ensure adequate oxygenation and ventilation. Intravenous access should be established, and gastric lavage after intubation, if patient is unconscious and administration of activated charcoal together with a laxative should be considered. The possibility of obtundation, seizure, or dystonic reaction of the head and neck following overdose may create a risk of aspiration with induced emesis. arava prescription discount
Ziprasidone and other drugs that prolong the QT interval have not been performed. An additive effect of Ziprasidone and other drugs that prolong the QT interval cannot be excluded. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. It is important to continue taking this medication even if you feel well. Do not stop taking this medication without consulting your doctor. Efficacy in schizophrenia was demonstrated in a dose range of 20 mg to 100 mg twice daily in short-term, placebo-controlled clinical trials. There were trends toward dose response within the range of 20 mg to 80 mg twice daily, but results were not consistent. An increase to a dose greater than 80 mg twice daily is not generally recommended. Because of its potential for inducing hypotension, Ziprasidone may enhance the effects of certain antihypertensive agents. Extrapyramidal Symptoms EPS The incidence of reported EPS which included the adverse reaction terms extrapyramidal syndrome, hypertonia, dystonia, dyskinesia, hypokinesia, tremor, paralysis and twitching for Ziprasidone-treated patients in the short-term, placebo-controlled schizophrenia trials was 14% vs. 8% for placebo. Objectively collected data from those trials on the Simpson-Angus Rating Scale for EPS and the Barnes Akathisia Scale for akathisia did not generally show a difference between Ziprasidone and placebo. Your doctor may want you to get additional laboratory tests to see if Ziprasidone hydrochloride capsule is an appropriate treatment for you. Discuss the risks and benefits with your doctor. buy dutasteride online dutasteride
Ziprasidone did not affect the pharmacokinetics of Ziprasidone. Antagonism at receptors other than dopamine and 5HT 2 with similar receptor affinities may explain some of the other therapeutic and side effects of Ziprasidone. Ziprasidone's antagonism of histamine H 1 receptors may explain the somnolence observed with this drug. Ziprasidone's antagonism of α 1-adrenergic receptors may explain the orthostatic hypotension observed with this drug. Withdrawal of antipsychotic drugs after long-term therapy should always be gradual and closely monitored to avoid the risk of acute withdrawal syndromes or rapid relapse. If you recognize that you're having trouble, you can be admitted voluntarily. But if you think you don't need help when you really do, the law may allow a doctor or other mental health professional to admit you involuntarily. Ziprasidone can affect your heart's rhythm. Other drugs can have the same effect. Ziprasidone patients compared to no median weight change in placebo patients. periactin
The risk is about 1 in 200 patients. Patients with an established diagnosis of diabetes mellitus who are started on atypical antipsychotics should be monitored regularly for worsening of glucose control. Several instruments were used for assessing psychiatric signs and symptoms in these studies. The Brief Psychiatric Rating Scale BPRS and the Positive and Negative Syndrome Scale PANSS are both multi-item inventories of general psychopathology usually used to evaluate the effects of drug treatment in schizophrenia. The BPRS psychosis cluster conceptual disorganization, hallucinatory behavior, suspiciousness, and unusual thought content is considered a particularly useful subset for assessing actively psychotic schizophrenic patients. A second widely used assessment, the Clinical Global Impression CGI reflects the impression of a skilled observer, fully familiar with the manifestations of schizophrenia, about the overall clinical state of the patient. In addition, the Scale for Assessing Negative Symptoms SANS was employed for assessing negative symptoms in one trial. Positive, encouraging support from family and friends really helps, too. If any of these effects persist or worsen, tell your doctor or promptly. QTc intervals exceeding the potentially clinically relevant threshold of 500 msec. In the Ziprasidone-treated patients, neither case suggested a role of Ziprasidone. One patient had a history of prolonged QTc and a screening measurement of 489 msec; QTc was 503 msec during Ziprasidone treatment. The other patient had a QTc of 391 msec at the end of treatment with Ziprasidone and upon switching to thioridazine experienced QTc measurements of 518 and 593 msec. Ziprasidone may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. The Journal of Pharmacology and Experimental Therapeutics. Older adults may be more sensitive to the side effects of this drug, especially dizziness, uncontrolled movements, and QT prolongation see above. Cardiovascular monitoring should commence immediately and should include continuous electrocardiographic monitoring to detect possible arrhythmias. If antiarrhythmic therapy is administered, disopyramide, procainamide, and quinidine carry a theoretical hazard of additive QT-prolonging effects that might be additive to those of Ziprasidone.
Call your doctor immediately if you take more than the amount of Ziprasidone hydrochloride capsules prescribed by your doctor. The FDA approved ziprasidone as a treatment for in February 2001. Miceli JJ, Glue P, Alderman J, Wilner K 2007. "The effect of food on the absorption of oral ziprasidone". Psychopharmacology Bulletin. This medicine may be harmful if swallowed. Take Ziprasidone hydrochloride capsules only as directed by your doctor. buy estreva 5mg online
If you get the medication in these areas, rinse with plenty of water. If irritation occurs or continues, contact your doctor right away. Seeger TF, Seymour PA, Schmidt AW, et al. October 1995. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. Ziprasidone is not removed by hemodialysis. Also, tell your doctor if you low levels of potassium or magnesium in your blood, if you use or have ever used street drugs or have overused prescription medications, or have trouble swallowing. Also tell your doctor if you have severe diarrhea or vomiting or you think you may be dehydrated. Since medications of the same drug class as Ziprasidone hydrochloride may interfere with the ability of the body to adjust to heat, it is best to avoid situations involving high temperature or humidity. Ziprasidone at a dose of 40 mg twice daily administered concomitantly with lithium at a dose of 450 mg twice daily for 7 days did not affect the steady-state level or renal clearance of lithium. Journal of Central Nervous System Disease. Retrieved October 16, 2016. Although it's a lifelong illness, you can take medicines and find help to stop symptoms or make them easier to live with. Ziprasidone is known to cause activation into mania in some bipolar patients. Only your doctor can decide if Ziprasidone hydrochloride capsules are right for you. Elderly patients with a diagnosis of psychosis related to dementia. Ziprasidone hydrochloride capsules are not approved for the treatment of these patients. One case of priapism was reported in the premarketing database. While the relationship of the reaction to Ziprasidone use has not been established, other drugs with alpha-adrenergic blocking effects have been reported to induce priapism, and it is possible that Ziprasidone may share this capacity. Severe priapism may require surgical intervention. eklov.info retin-a
For a list of all side effects that have been reported, ask your doctor or pharmacist for the Ziprasidone hydrochloride capsules Professional Package Insert. Ziprasidone hydrochloride capsules contain a monohydrochloride, monohydrate salt of Ziprasidone. Anything that can increase the chance of a heart rhythm abnormality should be avoided. Additionally, population pharmacokinetic evaluation of patients in controlled trials has revealed no evidence of clinically significant age or gender-related differences in the pharmacokinetics of Ziprasidone. Dosage modifications for age or gender are, therefore, not recommended. Davis R, Risch SC April 2002. The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using ziprasidone, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems heart failure, recent heart attack, slow heartbeat, QT prolongation in the EKG family history of certain heart problems QT prolongation in the EKG, sudden cardiac death. This list is not complete and there may be other drugs that should not be taken at the same time as ziprasidone. Tell your doctor about all medicines you use. This summary contains important information about Ziprasidone hydrochloride capsules. It is not meant to take the place of your doctor's instructions. Read this information carefully before you take Ziprasidone hydrochloride capsules. Ask your doctor or pharmacist if you do not understand any of this information or if you want to know more about Ziprasidone hydrochloride capsules. Because of this, Ziprasidone hydrochloride should be used only after your doctor has considered this risk for Ziprasidone hydrochloride against the risks and benefits of other medications available for treating schizophrenia. Once your delusions are under control, counseling can help you get along with others, hold a job, go to school, take care of yourself, and have friends. Ziprasidone and placebo patients, respectively. United Kingdom: Royal Pharmaceutical Society of Great Britain. Swallow the capsules whole. Ziprasidone frequently causes 1 in 7 patients. Therefore, care should be exercised in any activity requiring mental alertness, such as operating a motor vehicle including automobiles or operating hazardous machinery. Less common side effects include 1 in 250 patients. Hagop S. Akiskal; Mauricio Tohen June 24, 2011. aldactone
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Retrieved February 2, 2016. Given these considerations, Ziprasidone should be prescribed in a manner that is most likely to minimize the occurrence of tardive dyskinesia. Chronic antipsychotic treatment should generally be reserved for patients who suffer from a chronic illness that 1 is known to respond to antipsychotic drugs, and 2 for whom alternative, equally effective, but potentially less harmful treatments are not available or appropriate. In patients who do require chronic treatment, the smallest dose and the shortest duration of treatment producing a satisfactory clinical response should be sought. The need for continued treatment should be reassessed periodically.
Keating AM, Aoun SL, Dean CE 2005. This drug may rarely make your blood sugar level rise, which can cause or worsen diabetes. Tell your doctor right away if you develop symptoms of high blood sugar, such as increased thirst and urination. If you already have diabetes, be sure to check your blood sugars regularly. Your doctor may need to adjust your diabetes medication, exercise program, or diet. Ziprasidone hydrochloride capsules, 80 mg are size '2' capsules with dark blue opaque cap and white opaque body, imprinted axially with "LU" on cap and "V54" on body in black ink, containing off-white to pinkish granular powder.
In the second phase of the study, the effect of Ziprasidone on QTc length was not augmented by the presence of a metabolic inhibitor ketoconazole 200 mg twice daily. Use this on the only. However, not use it on the face or underarms unless directed to do so by your doctor. Some products are meant to be used on the scalp for various conditions. To correctly use these products, follow the directions on the product package. The possibility of a suicide attempt is inherent in psychotic illness and close supervision of high-risk patients should accompany drug therapy. Prescriptions for Ziprasidone should be written for the smallest quantity of capsules consistent with good patient management in order to reduce the risk of overdose.
RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. Please refer to the patient package insert. To assure safe and effective use of Ziprasidone hydrochloride capsules, the information and instructions provided in the patient information should be discussed with patients.